Both the Spurs and Reds have had a roller coaster campaign so far this season.
Tottenham manager Harry Redknapp believes that his side needs to prove they are fearsome on the pitch and be taken more seriously as a contender for the title.
The London-based side might be feeling a bit of fatigue after their midweek game Champions League match against Werder Bremen.
For Liverpool, that fear they once had may be gone, as two seasons ago they were only four points from winning the league.
The Reds’ season however is finally looking up after gaining 13 points from their last six games.
A win over Spurs with a two goal margin will even see Liverpool above the Spurs on the Premier League table, as they are currently only three points behind.
Liverpool’s away record this season however has been very poor, winning only once against Bolton.
Defender Jamie Carragher will also be making his 450th league appearance, and will take over the captain’s armband from currently sidelined Steven Gerrard.
Tottenham will be without Huddlestone and O’Hara, who are suffering an ankle and back injury respectively, and also Dos Santos, King and Woodgate, all of which have groin injuries.
Van der Vaart, Dawson and Jenas are all a possibility, providing they are fit enough after their injuries.
Meanwhile, Liverpool will still be without Gerrard, who picked up a hamstring injury during the last international match against France a couple weeks ago.
Other Liverpool injuries include Agger and Spearing, both with ankle injuries.
Midfielder Joe Cole is on the race to be fit following a hamstring injury.