Liverpool will surely walk through the tunnel at Anfield tomorrow with their heads held high after a big win over Chelsea last Sunday.
The Merseyside Reds are seeking their fifth consecutive win to put them even closer to a Champions League position.
Wigan will face a fitness boost with the return of midfielder James McCarthy from an ankle injury. However, defender Gary Caldwell could still be sidelined after fracturing his cheekbone, but may still play with a face mask.
Although he missed the England friendly against Denmark this week due to a groin issue, captain Steven Gerrard will be available for the Reds.
Defenders Martin Kelly and Martin Skrtel are both doubtful with their ankle and thigh injuries, respectively. Midfielder Joe Cole is also a doubt with his knee injury.
New signing Luis Suarez is expected to be on the pitch at some point, but his fellow new striker Andy Carroll is still fighting for fitness with a thigh injury.
Kick-off is at 3pm.